Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinyl-4,5-dimethylpyridazine
Reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[C:6]([CH3:9])[C:7]=1[CH3:8].O.[NH2:12][NH2:13]>O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:12][NH2:13])=[C:6]([CH3:9])[C:7]=1[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
3,6-Dichloro-4,5-dimethylpyridazine (W4.006; 29.0 g) was admixed with 160 ml of hydrazine monohydrate solution (160 ml) and heated to 90° C. while stirring for 4 h. The reaction mixture was admixed with water and the precipitate was filtered off with suction, washed with water and dried over phosphorus pentoxide. 27.2 g of the title compound were obtained.
Workup
- filtrationthe precipitate was filtered off with suction
- washwashed with water
- dry with materialdried over phosphorus pentoxide
Sources & evidence
- ORD record
- ord-7172efe03999411cb5cd199afe862700
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08198272B2
Reaction notes
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