Hydrazine hydrate (1:1) → HCID 55279275, compound

HRID 217700Notes

Reaction equation

HRID 217700 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[C:6]([CH3:10])[C:7]=1[CH2:8][CH3:9].O.[NH2:13][NH2:14]>O1CCOCC1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:13][NH2:14])=[C:6]([CH3:10])[C:7]=1[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57431053HCID 57431053, compound

Product 1

HCID 55279275HCID 55279275, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3,6-Dichloro-4-ethyl-5-methylpyridazine (W4.007; 1 g) was initially charged in dioxane (8 ml) with addition of hydrazine monohydrate (2 ml) in a microwave vessel at RT. Thereafter, the reaction mixture was kept at 140° C. in the microwave for 1 h. In the course of standing overnight, a solid precipitated out, which was filtered off with suction, washed and dried. 345 mg of (6-chloro-5-ethyl-4-methylpyridazin-3-yl)hydrazine were obtained as the free base.

Workup

  1. waitIn the course of standing overnight
  2. customa solid precipitated out
  3. filtrationwhich was filtered off with suction
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-fd714cc6cac14ef3b98b38e9d1d979ab
Source dataset
uspto-grants-2012_06
Patent number
US08198272B2

Reaction notes

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