Hydrochloric Acid → HCID 57467210, compound

HRID 2177081Notes

Reaction equation

HRID 2177081 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH:19]([F:21])[F:20])=[CH:13][CH:14]=2)[CH:9]1[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)(C)(C)C.Cl>ClCCl>[ClH:29].[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH:9]2[C:10]3[C:15](=[CH:14][CH:13]=[C:12]([O:18][CH:19]([F:21])[F:20])[CH:11]=3)[CH2:16][CH2:17][CH:8]2[NH2:7])=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57467212HCID 57467212, compound

Product 1

HCID 57467210HCID 57467210, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl[1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (30 mg, 0.069 mmol) was dissolved in dichloromethane (2 mL). 5N isopropanolic hydrochloric acid (0.3 mL) were added and the reaction mixture was stirred at room temperature for 3 h. The solvents were evaporated in vacuo. Yield: 26 mg (0.069 mmol, 100%, colorless solid).

Workup

  1. customThe solvents were evaporated in vacuo

Sources & evidence

ORD record
ord-5137dc688c204defbc96b351a7ca6e0d
Source dataset
uspto-grants-2015_06
Patent number
US09067871B2

Reaction notes

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