HCID 90418485, compound → HCID 90418272, compound

HRID 2177302Notes

Reaction equation

HRID 2177302 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][N:12]=[C:11]([C:14]([CH3:16])=[CH2:15])[C:10]=1[C:17]#[N:18].[H][H]>C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:13][N:12]=[C:11]([CH:14]([CH3:16])[CH3:15])[C:10]=1[C:17]#[N:18]

Participants

4

Reactant 2

HCID 90418485HCID 90418485, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 90418272HCID 90418272, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
20 °C

Procedure

Into a 25-mL 3-necked round-bottom flask, was placed 5-(2-fluoro-4-methylphenyl)-3-(prop-1-en-2-yl)-1,2-thiazole-4-carbonitrile (140 mg, 0.54 mmol, 1.00 equiv), ethyl acetate (10 mL), Pd(no water)/C (140 mg). To the above hydrogen gas was introduced. The resulting solution was stirred for 2 h at 20° C. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 130 mg (crude) of 5-(2-fluoro-4-methylphenyl)-3-(propan-2-yl)-1,2-thiazole-4-carbonitrile as a solid.

Workup

  1. customInto a 25-mL 3-necked round-bottom flask, was placed
  2. filtrationThe solids were filtered out
  3. concentrationThe resulting mixture was concentrated under vacuum
  4. customThis resulted in 130 mg (crude) of 5-(2-fluoro-4-methylphenyl)-3-(propan-2-yl)-1,2-thiazole-4-carbonitrile as a solid

Sources & evidence

ORD record
ord-75dfdff450454817a03c9acba920676c
Source dataset
uspto-grants-2015_06
Patent number
US09067898B1

Reaction notes

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