2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride → Rac-n-(3-cyclohexyl-1-methyl-piperidin-3-yl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 2177540Notes

Reaction equation

HRID 2177540 reaction equation
[CH:1]1([C:7]2([NH2:14])[CH2:12][CH2:11][CH2:10][N:9]([CH3:13])[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:15][O:16][C:17]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([S:30][CH3:31])[C:18]=1[C:19](Cl)=[O:20]>>[CH:1]1([C:7]2([NH:14][C:19](=[O:20])[C:18]3[C:22]([S:30][CH3:31])=[CH:23][C:24]([C:26]([F:29])([F:27])[F:28])=[CH:25][C:17]=3[O:16][CH3:15])[CH2:12][CH2:11][CH2:10][N:9]([CH3:13])[CH2:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 594385012-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chlorideHCID 59438512Rac-3-cyclohexyl-1-methyl-piperidin-3-ylamine

Product 1

HCID 59438488Rac-n-(3-cyclohexyl-1-methyl-piperidin-3-yl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Procedure

In analogy to the procedure described for the synthesis of example 16, the title compound was prepared from rac-3-cyclohexyl-1-methyl-piperidin-3-ylamine (Example A.11) and 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride (Example B6). MS (m/e): 445.2 (MH+).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 16

Sources & evidence

ORD record
ord-3cfef8b66159419993dcb692614d7260
Source dataset
uspto-grants-2015_06
Patent number
US09067911B2

Reaction notes

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