4-Fluoroaniline → 1-(4-fluorophenyl)-7-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine

HRID 2177639Notes

Reaction equation

HRID 2177639 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[CH:4][C:3]=1[CH3:11].ClC1C=C[N:16]=CC=1[N+]([O-])=O.[F:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][CH:24]=1.NC1C=CC=CN=1>>[F:22][C:23]1[CH:29]=[CH:28][C:26]([N:27]2[C:2]3[C:3]([CH3:11])=[CH:4][N:5]=[CH:6][C:7]=3[N:8]=[N:16]2)=[CH:25][CH:24]=1

Participants

5

Reactant 4

HCID 97314-FluoroanilineHCID 104392-AminopyridineHCID 27357814-Chloro-3-nitropyridineHCID 588823714-Chloro-3-methyl-5-nitropyridine

Product 1

HCID 904096921-(4-fluorophenyl)-7-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine

Procedure

The title compound was prepared in a manner analogous to Intermediate 17, Step 1 through Intermediate 19, Step 3 substituting 4-chloro-3-methyl-5-nitro-pyridine for 4-chloro-3-nitropyridine and 4-fluoroaniline for 2-aminopyridine in the synthesis of Intermediate 17, Step 1. MS (ESI) mass calcd. C12H9FN4, 228.1. m/z found, 229.1 [M+H]+.

Sources & evidence

ORD record
ord-64d4e4e8d90f4377ba776133b40a2492
Source dataset
uspto-grants-2015_06
Patent number
US09066946B2

Reaction notes

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