Hydrochloric Acid → 6-(Benzenesulphonylmethyl)-2-(2-dimethylaminoethoxy)-3-(furan-3-yl)benzoic acid hydrochloride

HRID 2177676Notes

Reaction equation

HRID 2177676 reaction equation
[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([O:19]C)=[O:18])=[C:15]([O:21][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])[C:14]([C:27]3[CH:31]=[CH:30][O:29][CH:28]=3)=[CH:13][CH:12]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>>[ClH:32].[C:1]1([S:7]([CH2:10][C:11]2[C:16]([C:17]([OH:19])=[O:18])=[C:15]([O:21][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])[C:14]([C:27]3[CH:31]=[CH:30][O:29][CH:28]=3)=[CH:13][CH:12]=2)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67107506Methyl 6-(benzenesulphonylmethyl)-2-(2-dimethylaminoethoxy)-3-(furan-3-yl)benzoate2×

Product 1

HCID 529146426-(Benzenesulphonylmethyl)-2-(2-dimethylaminoethoxy)-3-(furan-3-yl)benzoic acid hydrochloride

Procedure

Prepared by proceeding in a similar manner to Example 3, starting from methyl 6-(benzenesulphonylmethyl)-2-(2-dimethylaminoethoxy)-3-(furan-3-yl)benzoate (Intermediate 17). The product after chromatography was treated with hydrochloric acid (1M) and then evaporated to dryness. The residue was triturated with ether and the solid was collected by filtration.

Workup

  1. customPrepared
  2. customevaporated to dryness
  3. customThe residue was triturated with ether
  4. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-5b802dcb8fbe41d39897e0c45d815ad7
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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