Hydrochloric Acid → Methyl 2-(3-aminopropyl)-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoate

HRID 2177679Notes

Reaction equation

HRID 2177679 reaction equation
Cl.[C:2]1([S:8]([CH2:11][C:12]2[C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([CH2:22][CH2:23][CH2:24][NH:25]C(OC(C)(C)C)=O)[C:15]([C:33]3[CH:37]=[CH:36][O:35][CH:34]=3)=[CH:14][CH:13]=2)(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1.O>[NH2:25][CH2:24][CH2:23][CH2:22][C:16]1[C:15]([C:33]2[CH:37]=[CH:36][O:35][CH:34]=2)=[CH:14][CH:13]=[C:12]([CH2:11][S:8]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)(=[O:10])=[O:9])[C:17]=1[C:18]([O:20][CH3:21])=[O:19]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67107639Methyl 6-(benzenesulphonylmethyl)-2-(3-t-butoxycarbonylaminopropyl)-3-(furan-3-yl)benzoate2×

Product 1

HCID 67108214Methyl 2-(3-aminopropyl)-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoate

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Concentrated hydrochloric acid was added to a solution of methyl 6-(benzenesulphonylmethyl)-2-(3-t-butoxycarbonylaminopropyl)-3-(furan-3-yl)benzoate (Intermediate 131) in 1,4-dioxane (8 ml) and water (2 ml) and the mixture was stirred for 30 minutes. This was evaporated to dryness and the residue was purified by chromatography on silica eluting with a mixture of DCM:MeOH:AcOH:water (120:15:3:2) to give methyl 2-(3-aminopropyl)-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoate as a colourless gum. This material was dissolved in a mixture of dioxane and water (3:1) and lithium hydroxide monohydrate (0.188 g) was added. The reaction was heated in the microwave at 150° C. for one hour. After cooling, concentrated hydrochloric acid was added and the mixture was evaporated to dryness. The residue was purified by chromatography on silica eluting with a mixture of DCM:MeOH:AcOH:water (240:20:3:2), then again with DCM:MeOH:AcOH:water (120:15:3:2). The volume of the product containing fractions was reduced to 5 ml by evaporation and concentrated hydrochloric acid (1 ml) was added to the mixture. The mixture was evaporated to dryness and the residue was triturated with diethyl ether and the solid was collected by filtration and dried under vacuum at 60° C. to give 2-(3-aminopropyl)-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoic acid hydrochloride (0.045 g), as a white solid.

Workup

  1. customThis was evaporated to dryness
  2. customthe residue was purified by chromatography on silica eluting with a mixture of DCM:MeOH:AcOH:water (120:15:3:2)

Sources & evidence

ORD record
ord-414612af89504fd59bed8b818170b824
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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