Hydrochloric Acid → HCID 52913294, compound

HRID 2177682Notes

Reaction equation

HRID 2177682 reaction equation
[C:1]1([S:7]([CH2:10][C:11]2[C:12]([C:34]([OH:36])=[O:35])=[C:13]([C:26]([C:29]3[CH:33]=[CH:32][O:31][CH:30]=3)=[CH:27][CH:28]=2)[O:14][CH:15]2[CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:37]>>[ClH:37].[NH:17]1[CH2:18][CH:15]([O:14][C:13]2[C:26]([C:29]3[CH:33]=[CH:32][O:31][CH:30]=3)=[CH:27][CH:28]=[C:11]([CH2:10][S:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:8])=[O:9])[C:12]=2[C:34]([OH:36])=[O:35])[CH2:16]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67107582HCID 67107582, compound2×

Product 1

HCID 52913294HCID 52913294, compound

Procedure

Prepared by proceeding in a similar manner to Example 38, starting from t-butyl 3-[3-(benzenesulphonylmethyl)-2-carboxy-6-(furan-3-yl)phenoxy]-azetidine-1-carboxylate (Intermediate 167). The crude product was dissolved in HCl (4M in dioxane, 0.5 ml) and then evaporated to dryness. The residue was triturated with diethyl ether and the solid was collected by filtration to give 2-(azetidin-3-yloxy)-6-(benzenesulphonylmethyl)-3-(furan-3-yl)benzoic acid hydrochloride salt.

Workup

  1. customPrepared
  2. customevaporated to dryness
  3. customThe residue was triturated with diethyl ether
  4. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-35707950d321400781baf07cb8746d75
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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