反应详情

The product of step (vi) (14.5 g, 31.3 mmol) was added to a plastic vessel and THF (150 mL) added. HF (30 mL) was added carefully to the solution and the solution stirred at room temperature for 3 hours. The mixture was poured to 600 mL of water and 5 N—NaOH added to basify the solution to pH=10-11. The solution was extracted with EtOAc and washed with water (×3). The combined EtOAc extract was dried over MgSO4, filtered and concentrated in vacuo, which afforded the subtitle compound (vii) as a yellow solid (10 g).

1. additionHF (30 mL) was added carefully to the solution
2. additionadded
3. extractionThe solution was extracted with EtOAc
4. washwashed with water (×3)
5. extractionThe combined EtOAc extract
6. dry with materialwas dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo, which