Benzenesulfonic Acid → 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-besylate

HRID 217779Notes

Reaction equation

HRID 217779 reaction equation
[NH2:1][C:2]1[C:3]([C:23]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[O:24])=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:32]1([S:38]([OH:41])(=[O:40])=[O:39])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>CC(O)C>[S:38]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([OH:41])(=[O:40])=[O:39].[NH2:1][C:2]1[C:3]([C:23]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[O:24])=[N:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])=[CH:12][CH:13]=2)=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 7371Benzenesulfonic AcidHCID 533023753-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide

Product 1

HCID 533271753-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-besylate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

500.6 mg of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide (as prepared in Example 2) and 189.09 mg of Benzenesulfonic acid were accurately weighed into a glass vial and the 15 mL IPA was added to form a suspension. The suspension was kept shaking for 2 days at room temperature, and then filtered and dried at room temperature to yield a yellow powder.

Workup

  1. customto form a suspension
  2. filtrationfiltered
  3. customdried at room temperature
  4. customto yield a yellow powder

Sources & evidence

ORD record
ord-23c96e7b57a645ef83232db024077740
Source dataset
uspto-grants-2012_06
Patent number
US08198285B2

Reaction notes

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