HRID217779

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7371

Benzenesulfonic acid

C6H6O3S

结构：COCCCNCCCc1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1

HCID53302375

未命名化合物

PRODUCTS

生成物

结构：COCCCNCCCc1ccc(-c2cnc(N)c(C(=O)Nc3cccnc3)n2)cc1.O=S(=O)(O)c1ccccc1

HCID53327175

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

500.6 mg of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide (as prepared in Example 2) and 189.09 mg of Benzenesulfonic acid were accurately weighed into a glass vial and the 15 mL IPA was added to form a suspension. The suspension was kept shaking for 2 days at room temperature, and then filtered and dried at room temperature to yield a yellow powder.

WORKUP

后处理

customto form a suspension
filtrationfiltered
customdried at room temperature
customto yield a yellow powder

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-23c96e7b57a645ef83232db024077740
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08198285B2
来源说明: uspto-grants-2012_06

反应 SMILES

[NH2:1][C:2]1[C:3]([C:23]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[O:24])=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:32]1([S:38]([OH:41])(=[O:40])=[O:39])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>CC(O)C>[S:38]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([OH:41])(=[O:40])=[O:39].[NH2:1][C:2]1[C:3]([C:23]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[O:24])=[N:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])=[CH:12][CH:13]=2)=[CH:6][N:7]=1