1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → Methyl 6-(benzenesulphonylmethyl)-3-ethyl-2-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzoate

Participants

Role	Name	HCID	Charge
Reactant	1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 11587208	—
Reactant	Ethyl 6-benzenesulphonylmethyl-3-(furan-3-yl)-2-hydroxybenzoate	HCID 67107629	—
Reactant	Methyl 6-(benzenesulphonylmethyl)-3-ethyl-2-(trifluoromethanesulphonyloxy)benzoate	HCID 86677116	—
Product	Methyl 6-(benzenesulphonylmethyl)-3-ethyl-2-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]benzoate	HCID 67107802	—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 36, starting from methyl 6-(benzenesulphonylmethyl)-3-ethyl-2-(trifluoromethanesulphonyloxy)benzoate (Intermediate 127) and 1-(2-tetrahydropyranyl)-1H-pyrazole-5-boronic acid pinacol ester as an opaque foam which was used without further characterization.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09067905B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-cc5daac8481843909d9a9c587955de90
Source note	uspto-grants-2015_06