Furan-3-boronic acid → Methyl 3-(furan-3-yl)-2-methoxy-6-(piperidin-1-ylsulphonylmethyl)benzoate

HRID 2177804Notes

Reaction equation

HRID 2177804 reaction equation
C1(S(CC2C(C(OCC)=O)=C(O)C([C:23]3[CH:27]=[CH:26][O:25][CH:24]=3)=CC=2)(=O)=O)C=CC=CC=1.Br[C:29]1[C:30]([O:49][CH3:50])=[C:31]([C:36]([CH2:39][S:40]([N:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)(=[O:42])=[O:41])=[CH:37][CH:38]=1)[C:32]([O:34][CH3:35])=[O:33].O1C=CC(B(O)O)=C1>>[O:25]1[CH:26]=[CH:27][C:23]([C:29]2[C:30]([O:49][CH3:50])=[C:31]([C:36]([CH2:39][S:40]([N:43]3[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]3)(=[O:42])=[O:41])=[CH:37][CH:38]=2)[C:32]([O:34][CH3:35])=[O:33])=[CH:24]1

Participants

4

Reactant 3

HCID 2734358Furan-3-boronic acidHCID 67107629Ethyl 6-benzenesulphonylmethyl-3-(furan-3-yl)-2-hydroxybenzoateHCID 69915004HCID 69915004, compound2×

Product 1

HCID 69915016Methyl 3-(furan-3-yl)-2-methoxy-6-(piperidin-1-ylsulphonylmethyl)benzoate

Procedure

Prepared by proceeding in a similar manner to Intermediate 36, starting from methyl 3-bromo-2-methoxy-6-(piperidin-1-ylsulphonylmethyl)benzoate (Intermediate 147) and furan-3-boronic acid as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8846804073a14d55a89eec33c97d6185
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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