Sodium Sulfite → HCID 87271490, compound

HRID 2177805Notes

Reaction equation

HRID 2177805 reaction equation
[Br:1][C:2]1[C:3]([O:14][CH3:15])=[C:4]([C:9]([CH2:12]Br)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[S:16]([O-:19])([O-:18])=[O:17].[Na+:20].[Na+]>C(O)C.O>[Na+:20].[Br:1][C:2]1[CH:11]=[CH:10][C:9]([CH2:12][S:16]([O-:19])(=[O:18])=[O:17])=[C:4]([C:5]([O:7][CH3:8])=[O:6])[C:3]=1[O:14][CH3:15]

Participants

5

Reactant 2

HCID 24437Sodium SulfiteHCID 66685947Methyl 3-bromo-6-bromomethyl-2-methoxybenzoate2×

Product 1

HCID 87271490HCID 87271490, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of methyl 3-bromo-6-bromomethyl-2-methoxybenzoate (Intermediate 89, 1.0 g) and sodium sulphite (0.445 g) in ethanol (1 ml) and water (10 ml) was stirred and heated at reflux for 2 hours. After cooling, the mixture was evaporated to dryness to give (4-bromo-3-methoxy-2-methoxycarbonylphenyl)-methanesulphonic acid sodium salt (1.07 g) as a white solid which was used without further characterization.

Workup

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. temperatureAfter cooling
  4. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-af507ccc3c1140baa1ca405e832ef905
Source dataset
uspto-grants-2015_06
Patent number
US09067905B2

Reaction notes

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