1-(3,5-Dichlorophenyl)-2-phenylethanone → 3'-Chloro-4'-fluoro-2-phenylacetophenone

HRID 2178035Notes

Reaction equation

HRID 2178035 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[C:6](Cl)[CH:7]=1.BrC1C=CC([F:25])=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[F:25]

Participants

3

Reactant 2

HCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanoneHCID 35430654-Bromo-2-chloro-1-fluorobenzene

Product 1

HCID 27575653'-Chloro-4'-fluoro-2-phenylacetophenoneYield 20%

Procedure

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-2-chloro-1-fluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 17 (110 mg, yield 20.0%).

Workup

  1. customPrepared
  2. customwas purified by column chromatography (PE:EtOAc=100:1)

Sources & evidence

ORD record
ord-7be9b38c5d5d43ada51055b423d2a61a
Source dataset
uspto-grants-2015_06
Patent number
US09067893B2

Reaction notes

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