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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2178035Generated: October 30, 2026

1-(3,5-Dichlorophenyl)-2-phenylethanone → 3'-Chloro-4'-fluoro-2-phenylacetophenone

https://huagongshe.com/reaction/2178035

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3,5-Dichlorophenyl)-2-phenylethanoneHCID 2758146—
Reactant4-Bromo-2-chloro-1-fluorobenzeneHCID 3543065—
Product3'-Chloro-4'-fluoro-2-phenylacetophenoneHCID 275756520%

Reaction Steps

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-2-chloro-1-fluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 17 (110 mg, yield 20.0%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09067893B2
Source datasetuspto-grants-2015_06
ORD IDord-7be9b38c5d5d43ada51055b423d2a61a
Source noteuspto-grants-2015_06