2-Fluoro-5-hydroxybenzonitrile → 5-chloro-4-(3-cyano-4-fluorophenoxy)-2-fluoro-N-(pyrimidin-2-yl)benzenesulfonamide

HRID 2178110노트

반응식

HRID 2178110 반응식
[Cl:1][C:2]1[C:3](F)=[CH:4][C:5]([F:29])=[C:6]([S:8]([N:11](CC2C=CC(OC)=CC=2OC)[C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:7]=1.[C:31]([C:33]1[CH:34]=[C:35]([OH:40])[CH:36]=[CH:37][C:38]=1[F:39])#[N:32]>>[Cl:1][C:2]1[C:3]([O:40][C:35]2[CH:36]=[CH:37][C:38]([F:39])=[C:33]([C:31]#[N:32])[CH:34]=2)=[CH:4][C:5]([F:29])=[C:6]([S:8]([NH:11][C:12]2[N:13]=[CH:14][CH:15]=[CH:16][N:17]=2)(=[O:9])=[O:10])[CH:7]=1

참가 물질

3

반응물 2

HCID 226124102-Fluoro-5-hydroxybenzonitrileHCID 580422645-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

생성물 1

HCID 1176530715-chloro-4-(3-cyano-4-fluorophenoxy)-2-fluoro-N-(pyrimidin-2-yl)benzenesulfonamide

실험 절차

The title compound was prepared according to the method described for Library Protocol 2 using 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide (WO2012004743) and 3-cyano-4-fluorophenol.

출처 및 근거

ORD 기록
ord-3b4dfac4af3c4af8ad1da541e615b70f
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067922B2

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