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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2178110Generated: October 26, 2026

2-Fluoro-5-hydroxybenzonitrile → 5-chloro-4-(3-cyano-4-fluorophenoxy)-2-fluoro-N-(pyrimidin-2-yl)benzenesulfonamide

https://huagongshe.com/reaction/2178110

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-5-hydroxybenzonitrileHCID 22612410—
Reactant5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamideHCID 58042264—
Product5-chloro-4-(3-cyano-4-fluorophenoxy)-2-fluoro-N-(pyrimidin-2-yl)benzenesulfonamideHCID 117653071—

Reaction Steps

The title compound was prepared according to the method described for Library Protocol 2 using 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide (WO2012004743) and 3-cyano-4-fluorophenol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09067922B2
Source datasetuspto-grants-2015_06
ORD IDord-3b4dfac4af3c4af8ad1da541e615b70f
Source noteuspto-grants-2015_06