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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2178112생성일: 2026년 10월 25일

3-Chloro-2-fluoro-5-hydroxypyridine → 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamide

https://huagongshe.com/reaction/2178112

반응식

참여 물질

역할이름HCID투입량
반응물3-Chloro-2-fluoro-5-hydroxypyridineHCID 22451555—
반응물3-cyano-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamideHCID 59436600—
생성물4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamideHCID 117653188—

반응 단계

The title compound was prepared according to the method described for Method Variation 1 using 3-cyano-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide (Preparation 2) and 3-chloro-2-fluoro-5-hydroxypyridine and then purified using silica gel column chromatography eluting with 30-35% EtOAc in heptanes.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09067922B2
출처 데이터셋uspto-grants-2015_06
ORD IDord-5e427315feae431dbc92cb1f7437f91f
출처 메모uspto-grants-2015_06