反应详情

温度

100 °C

To a solution of 2-bromo-5-chlorophenol (1 g, 4.8 mmol) in DMF/water (45 mL/5 mL) was added sodium chlorodifluoroacetate (1.95 g, 12.0 mmol) and cesium carbonate (3.14 g, 9.64 mmol), and the reaction mixture was heated to 100° C. for 4 hours. The reaction mixture was cooled and diluted with TBME (20 mL) and water (20 mL). The organic layer was collected, washed with saturated aqueous NaHCO3 solution, brine, dried over Na2SO4 and concentrated in vacuo to afford the title compound (1.21 g, 98%), which was used without further purification.

1. temperatureThe reaction mixture was cooled
2. customThe organic layer was collected
3. washwashed with saturated aqueous NaHCO3 solution, brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo