3-Chloro-4-fluorobenzenesulphonyl chloride → 3-chloro-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:4]=1[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][N:8]=1.[F:20][C:21]1[C:26]([Cl:27])=[CH:25][C:24]([S:28](Cl)(=[O:30])=[O:29])=[CH:23][CH:22]=1>>[Cl:27][C:26]1[CH:25]=[C:24]([S:28]([N:6]([CH2:5][C:4]2[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:3]=2[O:2][CH3:1])[C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][N:8]=2)(=[O:29])=[O:30])[CH:23]=[CH:22][C:21]=1[F:20]Participants
3
Procedure
The title compound was prepared according to the method described for Preparation 18 using N-(2,4-dimethoxybenzyl)-5-fluoropyridin-2-amine (Preparation 20) and 4-fluoro-5-chlorobenzenesulfonyl chloride.
Sources & evidence
- ORD record
- ord-74ce88b37d8c4168994ca27c7b623020
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09067922B2
Reaction notes
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