HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-fluorobenzene-1-sulfonyl chloride → 3-bromo-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-fluorobenzene-1-sulfonyl chloride | HCID 21886733 | — |
| Reactant | N-(2,4-dimethoxybenzyl)-5-fluoropyridin-2-amine | HCID 58042270 | — |
| Product | 3-bromo-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide | HCID 117653442 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 11 using N-(2,4-dimethoxybenzyl)-5-fluoropyridin-2-amine (Preparation 20) and 4-fluoro-5-bromobenzenesulfonyl chloride at 40° C. The residue was purified by silica gel column chromatography eluting with 10% EtOAc in heptanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067922B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-3b0c2c25d09440bbb363d4475e648001 |
| Source note | uspto-grants-2015_06 |