2-Chloro-4-fluorobenzonitrile → 5-Bromo-2-(4-cyano-3-chlorophenoxy)-3-fluorobenzonitrile

HRID 2178135Notes

Reaction equation

HRID 2178135 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([OH:10])=[C:6]([CH:9]=1)[C:7]#[N:8].[Cl:12][C:13]1[CH:20]=[C:19](F)[CH:18]=[CH:17][C:14]=1[C:15]#[N:16]>>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([O:10][C:19]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[C:13]([Cl:12])[CH:20]=2)=[C:6]([CH:9]=1)[C:7]#[N:8]

Participants

3

Reactant 2

HCID 1090002-Chloro-4-fluorobenzonitrileHCID 580769375-Bromo-3-fluoro-2-hydroxybenzonitrile

Product 1

HCID 1176532065-Bromo-2-(4-cyano-3-chlorophenoxy)-3-fluorobenzonitrile

Procedure

The title compound was prepared according to the method described for Preparation at 120° C. for 68 hours using 5-bromo-3-fluoro-2-hydroxybenzonitrile (WO 2006022374) and 2-chloro-4-fluorobenzonitrile.

Workup

  1. customdescribed for Preparation at 120° C. for 68 hours

Sources & evidence

ORD record
ord-80dae758a1da4423a27d1013731f4feb
Source dataset
uspto-grants-2015_06
Patent number
US09067922B2

Reaction notes

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