HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Difluoromethyl)pyridine-2-carboxylic acid → N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(difluoromethyl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Difluoromethyl)pyridine-2-carboxylic acid | HCID 23145481 | — |
| Reactant | (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 71663148 | — |
| Product | N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(difluoromethyl)picolinamide | HCID 71667736 | — |
Reaction Steps
The coupling of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (XI-1) and 5-(difluoromethyl)picolinic acid [J. D. Scott et al. WO2011044181 (2011)] following General Procedure G yielded the title compound as a colorless amorphous solid. MS: m/z=447.5 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067926B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-ca5578dd3dee4d6fb3bc6019a53ac8c3 |
| Source note | uspto-grants-2015_06 |