HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid → HCID 71668046, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid | HCID 57475856 | — |
| Reactant | (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine | HCID 71663148 | — |
| Product | HCID 71668046 | HCID 71668046 | — |
Reaction Steps
The coupling of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (XI-1) and 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid [D. Banner et al. WO2011069934 (2011)] following General Procedure F yielded the title compound as an off-white solid. MS: m/z=470.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067926B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1ffcad5e7b9144fd84aa388049d30f16 |
| Source note | uspto-grants-2015_06 |