2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 44134089, compound

HRID 217822Notes

Reaction equation

HRID 217822 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N:12]=[C:13]=[O:14].[NH2:15][C:16]1[CH:34]=[CH:33][C:19]([O:20][C:21]2[C:30]3[N:29]=[C:28]([CH3:31])[C:27](=[O:32])[NH:26][C:25]=3[N:24]=[CH:23][CH:22]=2)=[CH:18][C:17]=1[F:35]>>[F:35][C:17]1[CH:18]=[C:19]([O:20][C:21]2[C:30]3[N:29]=[C:28]([CH3:31])[C:27](=[O:32])[NH:26][C:25]=3[N:24]=[CH:23][CH:22]=2)[CH:33]=[CH:34][C:16]=1[NH:15][C:13]([NH:12][C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[F:1])=[O:14]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 46901090HCID 46901090, compound

Product 1

HCID 44134089HCID 44134089, compoundYield 81%

Procedure

Method F2 was used with 2-fluoro-5-trifluoromethyl-phenylisocyanate and 8-(4-amino-3-fluorophenoxy)-2-methylpyrido[2,3-b]pyrazin-3(4H)-one to afford the title compound, yield 81%.

Sources & evidence

ORD record
ord-f1ad0b05f68d4f319463b2b7d24d90a8
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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