反应详情

To a 5 mL microwave vial were added methyl 1-{[1-(3-bromobenzyl)-5-(quinolin-2-ylmethoxy)-1H-benzimidazol-2-yl]methyl}cyclopentanecarboxylate (62 mg, 0.1 mmol), Pd(dppf)Cl2 (8.3 mg, 0.01 mmol), phenylboronic acid (45 mg, 0.35 mmol), K3PO4 (78 mg, 0.37 mmol) and 1,4-dioxane (1.5 mL). The vial was flushed with N2 then capped and placed in a heating block at 100° C. After 6 h the mixture was cooled to RT, transferred to a round-bottomed flask, and concentrated to dryness. The residue was purified using FCC to provide the title compound. MS (ESI): mass calcd. for C38H35N3O3, 581.71; m/z found 582.1 [M+H]+.

1. customThe vial was flushed with N2
2. customthen capped
3. customplaced in a heating block at 100° C
4. customtransferred to a round-bottomed flask
5. concentrationconcentrated to dryness
6. customThe residue was purified