HCID 123164601, compound → HCID 89505938, compound

HRID 2178524Notes

Reaction equation

HRID 2178524 reaction equation
C[O:2][CH:3]=[CH:4][C:5]1[C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])=[N:7][CH:8]=[CH:9][CH:10]=1>C(O)=O.O>[O:17]=[C:12]1[CH2:13][CH2:14][CH2:15][CH2:16][N:11]1[C:6]1[C:5]([CH2:4][CH:3]=[O:2])=[CH:10][CH:9]=[CH:8][N:7]=1

Participants

4

Reactant 1

HCID 123164601HCID 123164601, compound

Product 1

HCID 89505938HCID 89505938, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

1-[3-(2-Methoxyethenyl)pyridin-2-yl]piperidin-2-one a4-2 (0.340 g, 1.464 mmol, 1 eq) is dissolved in a mixture of formic acid and water (10 ml/0.5 ml). The reaction mixture is heated at 50° C. overnight. The solvent is removed under reduced pressure to afford crude [2-(2-oxopiperidin-1-yl)pyridin-3-yl]acetaldehyde a4-3 which is used in the next step without any further purification.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-868747e48e4146b7adce69b3c4b5c00a
Source dataset
uspto-grants-2015_06
Patent number
US09067930B2

Reaction notes

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