2,3-Dichlorophenol → HCID 17370750, compound

HRID 2178708Notes

Reaction equation

HRID 2178708 reaction equation
[OH-].[K+].Br[C:4]([CH3:11])([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[OH:20]>>[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[O:20][C:4]([CH3:11])([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

4

Reactant 3

HCID 113342,3-DichlorophenolHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 14797Potassium Hydroxide

Product 1

HCID 17370750HCID 17370750, compound

Procedure

Potassium hydroxide-mediated reaction of ethyl 2-bromo-2-methylpropanoate with 2,3-dichlorophenol provided ethyl 2-(2,3-dichlorophenoxy)-2-methylpropanoate. After reduction to the corresponding aldehyde with diisobutylaluminum hydride, reductive amination with 2-aminoethanol provided the requisite 2-aminoethanol derivative.

Sources & evidence

ORD record
ord-3459c8a357344738a5d808ecae1e4fd6
Source dataset
uspto-grants-2015_06
Patent number
US09067934B2

Reaction notes

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