Aniline → HCID 178516132, compound

HRID 2178716Notes

Reaction equation

HRID 2178716 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:8][C:9]([F:19])([F:18])[C:10](=O)[CH2:11][C:12](OCC)=[O:13]>>[F:8][C:9]([F:19])([F:18])[C:10]1[CH:11]=[C:12]([OH:13])[C:7]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:1]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 67793Ethyl 4,4,4-trifluoroacetoacetate

Product 1

HCID 178516132HCID 178516132, compound

Procedure

A mixture of the appropriate aniline and ethyl 4,4,4-trifluoro-3-oxobutanoate may be treated with polyphosphoric acid to afford the requisite 2-(trifluoromethyl)quinolin-4-ol (see British Pat. Appl. GB 1419789 A 19751231).

Sources & evidence

ORD record
ord-b6f375d504cb41db8c01d49a64164ef8
Source dataset
uspto-grants-2015_06
Patent number
US09067934B2

Reaction notes

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