Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2178716Generated: October 31, 2026

Aniline → HCID 178516132, compound

https://huagongshe.com/reaction/2178716

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAnilineHCID 6115—
ReactantEthyl 4,4,4-trifluoroacetoacetateHCID 67793—
ProductHCID 178516132HCID 178516132—

Reaction Steps

A mixture of the appropriate aniline and ethyl 4,4,4-trifluoro-3-oxobutanoate may be treated with polyphosphoric acid to afford the requisite 2-(trifluoromethyl)quinolin-4-ol (see British Pat. Appl. GB 1419789 A 19751231).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09067934B2
Source datasetuspto-grants-2015_06
ORD IDord-b6f375d504cb41db8c01d49a64164ef8
Source noteuspto-grants-2015_06