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3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole → 4-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole | HCID 16043572 | — |
| 反応物 | 4-(Benzyloxy)-1-methyl-1H-indole | HCID 24776901 | — |
| 触媒 | Cuprous acetate | HCID 69023 | — |
| 生成物 | 4-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole | HCID 68379783 | — |
反応手順
4-(Benzyloxy)-1-methyl-1H-indole and 3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole were treated with copper(I) acetate to give 4-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole. Debenzylation via transfer hydrogenation with ammonium formate afforded 1-methyl-2-(trifluoromethyl)-1H-indol-4-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09067934B2 |
| 出典データセット | uspto-grants-2015_06 |
| ORD ID | ord-380d383cf6374bb3a8148a67c39f651b |
| 出典メモ | uspto-grants-2015_06 |