Aminoisobutyric acid → Ethyl 2-amino-2-methylpropanoate hydrochloride

HRID 2178730Notes

Reaction equation

HRID 2178730 reaction equation
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S1C=C[CH:10]=[C:9]1[Cl:13]>C(O)C>[ClH:13].[CH2:9]([O:4][C:3](=[O:5])[C:2]([NH2:1])([CH3:7])[CH3:6])[CH3:10]

Participants

4

Reactant 2

HCID 6119Aminoisobutyric acidHCID 72992-Chlorothiophene

Product 1

HCID 22343822Ethyl 2-amino-2-methylpropanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
5.400000095367432 °C

Procedure

Ethanol (400 L) was added to 2-aminoisobutyric acid (22.0 Kg). Thienyl chloride (30 Kg) was added to the mixture, maintaining the temperature at 5.40° C. The mixture was heated to reflux and stirred for a period of 4 to 6 hours. The reaction mixture was cooled to 5.40° C. The contents were distilled under atmospheric pressure to a residual volume of approximately 100 L.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. temperatureThe reaction mixture was cooled to 5.40° C
  4. distillationThe contents were distilled under atmospheric pressure to a residual volume of approximately 100 L

Sources & evidence

ORD record
ord-020749b7661e41338159464f56a1a79e
Source dataset
uspto-grants-2015_06
Patent number
US09067944B2

Reaction notes

Loading…