Aminoisobutyric acid → Ethyl 2-amino-2-methylpropanoate hydrochloride

Participants

Reaction Conditions

Reaction Steps

Ethanol (400 L) was added to 2-aminoisobutyric acid (22.0 Kg). Thienyl chloride (30 Kg) was added to the mixture, maintaining the temperature at 5.40° C. The mixture was heated to reflux and stirred for a period of 4 to 6 hours. The reaction mixture was cooled to 5.40° C. The contents were distilled under atmospheric pressure to a residual volume of approximately 100 L.

Provenance & Evidence