HCID 55238268, compound → 2-(1H-pyrazol-1-yl)-5-(trifluoromethyl)aniline

HRID 217874Notes

Reaction equation

HRID 217874 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH:18]=[CH:17][CH:16]=[N:15]1)([O-])=O>CCO>[N:14]1([C:5]2[CH:6]=[CH:7][C:8]([C:10]([F:11])([F:12])[F:13])=[CH:9][C:4]=2[NH2:1])[CH:18]=[CH:17][CH:16]=[N:15]1

Participants

3

Reactant 1

HCID 55238268HCID 55238268, compound

Product 1

HCID 70640332-(1H-pyrazol-1-yl)-5-(trifluoromethyl)anilineYield 48%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Method C3 was used 1-(2-nitro-4-(trifluoromethyl)phenyl)-1H-pyrazole (1.80 g, 7.00 mmol) in EtOH (40 mL) to give 760 mg (48%) of the title compound as white crystals after crystallization from hexane.

Sources & evidence

ORD record
ord-379a0809e0d646d786bfcacd8767ffe3
Source dataset
uspto-grants-2012_06
Patent number
US08198279B2

Reaction notes

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