Ethyl 3-(4-pyridyl)-3-oxopropionate → (+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione

HRID 217887Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 217887
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[N:3][CH:2]=1.N1C=CC(C(=O)CC(OCC)=O)=CC=1.Cl.[NH:30]=[C:31]1[CH:37]([N:38]2[C:46](=[O:47])[C:45]3[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=3)[C:39]2=[O:48])[CH2:36][CH2:35][CH2:34][CH2:33][NH:32]1>>[O:11]=[C:9]1[N:32]2[CH2:33][CH2:34][CH2:35][CH2:36][CH:37]([N:38]3[C:46](=[O:47])[C:45]4[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=4)[C:39]3=[O:48])[C:31]2=[N:30][C:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][N:3]=2)=[CH:8]1

Komponenten

4

Edukt 3

HCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 11961458Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoateHCID 178479134HCID 178479134, Verbindung

Produkt 1

HCID 67265833(+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione

Versuchsvorschrift

By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-iminoazepan-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1), the compound was obtained as a white powder.

Aufarbeitung

  1. customprepared by analogy to the method
  2. customthe compound was obtained as a white powder

Quellen und Nachweise

ORD-Eintrag
ord-530b84ffedda43a8bb41464d3c788eeb
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198287B2

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