Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 3-(4-pyridyl)-3-oxopropionate → (+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| 반응물 | Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate | HCID 11961458 | — |
| 반응물 | HCID 178479134 | HCID 178479134 | — |
| 생성물 | (+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione | HCID 67265833 | — |
반응 단계
By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-iminoazepan-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1), the compound was obtained as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198287B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-530b84ffedda43a8bb41464d3c788eeb |
| 출처 메모 | uspto-grants-2012_06 |