N-(2-Oxo-3-piperidyl)phthalimide → 2-(2-Methoxy-4,5-dihydro-3H-pyrrol-3-yl)isoindole-1,3-dione

HRID 217888Notes

Reaction equation

HRID 217888 reaction equation
[O:1]=[C:2]1[CH:6]([N:7]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:17])[CH2:5][CH2:4][NH:3]1.[C:18]1(=O)N(C2CCCNC2=O)C(=O)C2=CC=CC=C12>>[CH3:18][O:1][C:2]1[CH:6]([N:7]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:17])[CH2:5][CH2:4][N:3]=1

Participants

3

Reactant 2

HCID 135339N-(2-Oxo-3-piperidyl)phthalimideHCID 672658712-(2-Oxopyrrolidin-3-yl)isoindoline-1,3-dione

Product 1

HCID 672658062-(2-Methoxy-4,5-dihydro-3H-pyrrol-3-yl)isoindole-1,3-dione

Procedure

By analogy with the method described in example 1 (step 1.1), using 2-(2-Oxo-pyrrolidin-3-yl)-isoindole-1,3-dione (prepared by analogy to the method described in (Heterocycles (1996), 42(2), 537-42, Enantiomer (2001), 6(5), 275-279, Synthesis (1991), (5), 417-20)) in place of 3-phtalimidopiperidin -2-one, the compound was obtained as a white powder.

Workup

  1. customprepared by analogy to the method
  2. customthe compound was obtained as a white powder

Sources & evidence

ORD record
ord-fc3c78900e164f7cbdf28f70d35e43db
Source dataset
uspto-grants-2012_06
Patent number
US08198287B2

Reaction notes

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