HCID 86636837, compound → HCID 69023817, compound

HRID 217896Notes

Reaction equation

HRID 217896 reaction equation
[N:1]([C:4]1([CH3:22])[CH2:10][CH2:9][CH2:8][CH2:7][N:6]2[C:11](=[O:21])[CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[N:14]=[C:5]12)=[N+]=[N-]>[Pd]>[NH2:1][C:4]1([CH3:22])[CH2:10][CH2:9][CH2:8][CH2:7][N:6]2[C:11](=[O:21])[CH:12]=[C:13]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[N:14]=[C:5]12

Participants

3

Reactant 1

HCID 86636837HCID 86636837, compound

Product 1

HCID 69023817HCID 69023817, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

10-azido-10-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H -pyrimido[1,2-a]azepin-4-one was reduced by using H-Cube™ technology (from THALES Nanotechnology, full H2, Pd/C as catalyst, 1 mL/min and 50° C.). After an acid-basic work-up, (+/−)10-amino-1 0-methyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-pyrimido[1,2-a]azepin-4-one was obtained and the compound was used as such in the next step.

Sources & evidence

ORD record
ord-44d4ef30094c473e81d18033c0f2c6f2
Source dataset
uspto-grants-2012_06
Patent number
US08198287B2

Reaction notes

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