3-(2-Bromoacetyl)pyridine hydrobromide → HCID 71575799, compound

HRID 2179044Notes

Reaction equation

HRID 2179044 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([N:24]2[CH2:28][CH2:27][C:26]([F:30])([F:29])[CH2:25]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=C[C:18]=3Cl)=[O:16])[N:13]=2)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1[N:36]=C(N2CCC(F)(F)C2)C2N=NNC=2N=1)(C)(C)C.Br.BrCC(C1C=NC=CC=1)=O>>[C:1]([C:5]1[N:6]=[C:7]([N:24]2[CH2:28][CH2:27][C:26]([F:30])([F:29])[CH2:25]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][C:15]([C:17]3[CH:18]=[N:36][CH:20]=[CH:21][CH:22]=3)=[O:16])[N:13]=2)[N:10]=1)([CH3:3])([CH3:2])[CH3:4]

Participants

4

Reactant 3

HCID 27762343-(2-Bromoacetyl)pyridine hydrobromideHCID 89586134HCID 89586134, compoundHCID 178441789HCID 178441789, compound

Product 1

HCID 71575799HCID 71575799, compound

Procedure

In analogy to the procedure described for the synthesis of 2-[5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl]-1-(2-chloro-phenyl)-ethanone (example 47), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 2-bromo-1-(pyridin-3-yl)ethanone hydrobromide and isolated as light yellow solid. MS (m/e): 402.3 (MH+).

Workup

  1. customisolated as light yellow solid

Sources & evidence

ORD record
ord-53a94e687dba4c5a84cb71cb3eff77d4
Source dataset
uspto-grants-2015_06
Patent number
US09067943B2

Reaction notes

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