関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylsilane | HCID 12052 | — |
| 反応物 | 5-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 86683345 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | HCID 178441794 | HCID 178441794 | — |
反応手順
A mixture of 5-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and triethylsilane in TFA was heated to 70° C. for 22 h and evaporated to dryness. The residue was used without further purification in the consecutive step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09067943B2 |
|---|
| 出典データセット | uspto-grants-2015_06 |
|---|
| ORD ID | ord-5c9dcd62e3af48dd8a0163ebfb078f13 |
|---|
| 出典メモ | uspto-grants-2015_06 |
|---|
