HCID 86629757, compound → HCID 59382684, compound

HRID 217963Notes

Reaction equation

HRID 217963 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH:13]=[CH:14][CH:15]=1)#[CH:9]>C(OCC)(=O)C>[C:8]([C:10]1[CH:11]=[C:12]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH:13]=[CH:14][CH:15]=1)#[CH:9]

Participants

3

Reactant 1

HCID 86629757HCID 86629757, compound

Product 1

HCID 59382684HCID 59382684, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(piperidin-4-ylidene)acetamide trifluoroacetate was dissolved in ethyl acetate. The mixture was washed once with saturated Na2CO3 and once with brine, dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo to give the title product. MS (EI) 384 (M+1).

Workup

  1. washThe mixture was washed once with saturated Na2CO3 and once with brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-634de75cf80648a6b44c25043cb72f6c
Source dataset
uspto-grants-2012_06
Patent number
US08198301B2

Reaction notes

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