反应详情

60 mg (0.15 mmol) of 7-(2-aminophenyl)-N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide (Example 132), 20 μl (0.31 mmol) of cyclopropylcarbonyl chloride and 87 μl (0.62 mmol) of triethylamine are stirred in. 2 ml of THF/DMF (1:1) at RT overnight. After addition of water, the solvent is removed under reduced pressure. Purification takes place by preparative HPLC. The product is dissolved in methanol, and an excess of 1N hydrochloric acid is added. Removal of the solvent under reduced pressure and drying under high vacuum result in 27 mg (40% of theory) of the title compound.

1. customat RT
2. customovernight
3. customthe solvent is removed under reduced pressure
4. customPurification
5. dissolutionThe product is dissolved in methanol
6. additionan excess of 1N hydrochloric acid is added
7. customRemoval of the solvent under reduced pressure
8. customdrying under high vacuum