HCID 67312922, compound → HCID 9976826, compound

HRID 2179665Notes

Reaction equation

HRID 2179665 reaction equation
Cl.[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C@@H:4]([NH:10][C:11]([C:13]1[O:14][C:15]3[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[O:28][CH3:29])=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2>C(OCC)(=O)C>[N:2]12[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9]1)[C@@H:4]([NH:10][C:11]([C:13]1[O:14][C:15]3[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[O:28][CH3:29])=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2

Participants

3

Reactant 1

HCID 67312922HCID 67312922, compound

Product 1

HCID 9976826HCID 9976826, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

600 mg (1.45 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide hydrochloride (Example 102) are dissolved in 15 ml of ethyl acetate and extracted three times with 1N sodium hydroxide solution. The organic phase is dried over sodium sulphate and then concentrated. Drying under high vacuum results in 534 mg (97.6% of theory) of the title compound.

Workup

  1. extractionextracted three times with 1N sodium hydroxide solution
  2. dry with materialThe organic phase is dried over sodium sulphate
  3. concentrationconcentrated
  4. customDrying under high vacuum

Sources & evidence

ORD record
ord-1b7261d67d004c4985669241d04ab5cd
Source dataset
uspto-grants-2015_06
Patent number
US09067931B2

Reaction notes

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