HCID 68454721, compound → HCID 59382701, compound

HRID 217967Notes

Reaction equation

HRID 217967 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([NH:34][C:35](=[O:43])[CH:36]=[C:37]4[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]4)[CH:32]=3)[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>C(OCC)(=O)C>[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([NH:34][C:35](=[O:43])[CH:36]=[C:37]4[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]4)[CH:32]=3)[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 1

HCID 68454721HCID 68454721, compound

Product 1

HCID 59382701HCID 59382701, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-6-yl)-2-(piperidin-4-ylidene)acetamide trifluoroacetate was dissolved in ethyl acetate, washed once with saturated Na2CO3, and once with brine, dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo to give the title product. MS (EI) 501 (M+1).

Workup

  1. washwashed once with saturated Na2CO3
  2. dry with materialonce with brine, dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-e2ed666edfc248de8274b08e4a44c2b2
Source dataset
uspto-grants-2012_06
Patent number
US08198301B2

Reaction notes

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