Hydrogen Peroxide → HCID 58675220, compound

HRID 2179722Notes

Reaction equation

HRID 2179722 reaction equation
[OH:1]O.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:12]([C:14]1[O:15][C:16]3[C:22]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[O:29][CH3:30])=[CH:21][CH:20]=[CH:19][C:17]=3[CH:18]=1)=[O:13])[CH2:4]2>CO>[CH3:30][O:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:22]1[C:16]2[O:15][C:14]([C:12]([NH:11][C@@H:5]3[CH:6]4[CH2:7][CH2:8][N+:3]([O-:1])([CH2:10][CH2:9]4)[CH2:4]3)=[O:13])=[CH:18][C:17]=2[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 784Hydrogen Peroxide2×HCID 9976826HCID 9976826, compound

Product 1

HCID 58675220HCID 58675220, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

35.8 μl (0.35 mmol) of 30% strength hydrogen peroxide are added to a solution, cooled to 0° C., of 110 mg (0.29 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-methoxyphenyl)-1-benzofuran-2-carboxamide (Example 130) in 2 ml of methanol. After 18 h at room temperature, a further 35.8 μl (0.35 mmol) of 30% strength hydrogen peroxide are added. After a further 18 h at room temperature, the reaction solution is concentrated, and the residue is dried under high vacuum. 111.5 mg (97.2% of theory) of the title compound are obtained.

Workup

  1. waitAfter a further 18 h at room temperature
  2. concentrationthe reaction solution is concentrated
  3. customthe residue is dried under high vacuum

Sources & evidence

ORD record
ord-98a028367c664ab79241ba166d06dac4
Source dataset
uspto-grants-2015_06
Patent number
US09067931B2

Reaction notes

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