Triethylamine → HCID 58111022, compound

HRID 2179739Notes

Reaction equation

HRID 2179739 reaction equation
[CH3:1][C:2]1([CH3:22])[C@@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][C@H:3]1[NH:14]C(=O)OC(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:14][C@@H:3]1[CH2:4][C@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[C:2]1([CH3:22])[CH3:1]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 70803893HCID 70803893, compound

Product 1

HCID 58111022HCID 58111022, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Tert-butyl (1R,3S)-2,2-dimethyl-3-(morpholine-4-carbonyl)cyclobutylcarbamate (Step 1, 0.260 g, 0.833 mmol) was taken in TFA:DCM (1:4) (3 ml) at 0° C.-room temperature and stirred for 1 hour. After completion of the reaction the solvent was evaporated and the crude dissolved in DCM and basified with Et3N (0.7 ml, 5.0 mmol). The resulting solution as such used for next reaction immediately. Wt: 0.176 g.

Workup

  1. customAfter completion of the reaction the solvent
  2. customwas evaporated
  3. dissolutionthe crude dissolved in DCM
  4. customThe resulting solution as such used for next reaction immediately

Sources & evidence

ORD record
ord-5a5876f6a588474c8f65e636832d1790
Source dataset
uspto-grants-2015_06
Patent number
US09067966B2

Reaction notes

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