Trifluoroacetic acid → HCID 66858993, compound

HRID 2179746Notes

Reaction equation

HRID 2179746 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C@H:8]2[CH2:12][CH2:11][C@@H:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9]2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O.O1CCN(CC2CCC(N)C2)CC1>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][C@H:8]2[CH2:12][CH2:11][C@@H:10]([NH2:13])[CH2:9]2)[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 18453460HCID 18453460, compoundHCID 18453496HCID 18453496, compound

Product 1

HCID 66858993HCID 66858993, compound

Procedure

Tert-butyl (1R,3S)-3-(morpholinomethyl)cyclopentylcarbamate (Step 4, 0.6) was treated with trifluoroacetic acid (2 ml) and the obtained compound of 3-(morpholinomethyl)cyclopentanamine was used directly for synthesizing final compounds given in example section without further purification.

Sources & evidence

ORD record
ord-c13bb136ff444c898f381449fb32a783
Source dataset
uspto-grants-2015_06
Patent number
US09067966B2

Reaction notes

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