HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetohydrazide → 6'-(2-Hydroxypropyl)-4'-methoxy-4-nitrobenzophenone acetylhydrazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | 1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman | HCID 22488971 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6'-(2-Hydroxypropyl)-4'-methoxy-4-nitrobenzophenone acetylhydrazone | HCID 86584470 | 66.3% |
Reaction Steps
To a solution of 4 (1.6 g) in 25 ml of ethanol was added acetic hydrazide (0.4 g) and 2 drops of concentrated HCl. The resulting solution was heated to reflux for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product (1.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887867B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-a9a61f4ca8f04b30a8369b6436cc3cd4 |
| Source note | uspto-grants-2005_05 |