HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzaldehyde → 6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzaldehyde | HCID 541 | — |
| Reactant | 1-(3-Acetylamino-4-methoxyphenyl)-2-propyl Alcohol | HCID 69733722 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman | HCID 22488965 | 66% |
Reaction Steps
To a solution of compound 13 (0.23 g, 1.03 mmol) in 15 ml of HCl solution in 1,4-dioxane was added 4-nitrobenzaldehyde (0.16 g, 1.06 mmol) in one portion. After refluxing for 5 hours, the solvent was removed under reduced pressure. The residue was washed with cold ethanol three times, and dried to give the product 14 (0.21 g, 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887867B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-d67cf6e48b9e43c7bd676093637a3d43 |
| Source note | uspto-grants-2005_05 |